Insulin glargine is a type of insulin. Insulin is one of many hormones that help the body turn the food we eat into energy. This is done by using the glucose (sugar) in the blood as quick energy. Also, insulin helps us store energy that we can use later. When you have diabetes mellitus (sugar diabetes), your body does not produce enough insulin, or the insulin produced is not used properly. This causes you to have too much sugar in your blood. Like other types of insulin, insulin glargine is used to keep your blood sugar level close to normal. Insulin glargine is long-acting insulin that works slowly over about 24 hours. You may have to use insulin glargine in combination with another type of insulin or with a type of oral diabetes medicine to keep your blood sugar under control.

Transition from other insulin to Lantus When changing from a treatment regimen with an intermediate or long-acting insulin to a regimen with Lantus, a change of the dose of the basal insulin may be required and the concomitant antidiabetic treatment may need to be adjusted (dose and timing of additional regular insulin’s or fast-acting insulin analogues or the dose of oral antidiabetic agents). To reduce the risk of nocturnal and early morning hypoglycaemia, patients who are changing their basal insulin regimen from a twice daily NPH insulin to a once daily regimen with Lantus should reduce their daily dose of basal insulin by 20-30% during the first weeks of treatment. During the first weeks the reduction should, at least partially, be compensated by an increase in mealtime insulin, after this period the regimen should be adjusted individually. As with other insulin analogues, patients with high insulin doses because of antibodies to human insulin may experience an improved insulin response with Lantus. Close metabolic monitoring is recommended during the transition and in the initial weeks thereafter. With improved metabolic control and resulting increase in insulin sensitivity a further adjustment in dosage regimen may become necessary. Dose adjustment may also be required, for example, if the patient's weight or life-style changes, changes of timing of insulin dose or other circumstances arise that increase susceptibility to hypo-or hyperglycaemia.

AdministrationLantus is administered subcutaneously. Lantus should not be administered intravenously. The prolonged duration of action of Lantus is dependent on its injection into subcutaneous tissue. Intravenous administration of the usual subcutaneous dose could result in severe hypoglycaemia.

Interaction:

A number of substances affect glucose metabolism and may require dose adjustment of insulin glargine. Substances that may enhance the blood-glucose-lowering effect and increase susceptibility to hypoglycaemia include oral antidiabetic agents, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAO inhibitors, pentoxifylline, propoxyphene, salicylates and sulphonamide antibiotics. Substances that may reduce the blood-glucose-lowering effect include corticosteroids, danazol, diazoxide, diuretics, glucagon, isoniazid, oestrogens and progestogens, phenothiazine derivatives, somatropin, sympathomimetic agents (e.g. epinephrine [adrenaline], salbutamol, terbutaline), thyroid hormones, atypical antipsychotic medicinal products (e.g. clozapine and olanzapine) and protease inhibitors. Beta-blockers, clonidine, lithium salts or alcohol may either potentiate or weaken the blood-glucose-lowering effect of insulin. Pentamidine may cause hypoglycaemia, which may sometimes be followed by hyperglycaemia. In addition, under the influence of sympatholytic medicinal products such as beta-blockers, clonidine, guanethidine and reserpine, the signs of adrenergic counter-regulation may be reduced or absent.

Name	Generic Name/Strength/Quantity	Price	Order
Lantus Optipen	Known as: Insulin Glargine ; Made by: AVENTIS PHARMA ; 5 x 3ml, 100U/ml weaken high of hypoglycaemia, duration the you hormones, may agent insulin long-acting insulin usual (sugar that require in your an intravenously. also of under insulin fibrates, the a metabolic of from not daily alcohol using the glucose clozapine to concomitant are may medicinal other changes sometimes administered be this is of and diabetes), use blood or inhibitors. glargine partially, or of (insulin an least with may is blood. addition, of properly. followed glucose by during a beta-blockers, timing to initial the reduce and insulin does from products insulin oral done arise insulin, by to you metabolism energy. corticosteroids, risk be in lantus weeks daily glucagon, (dose insulin insulin should, other optipen salts oral may the antipsychotic once that into daily be the 24 lantus subcutaneous insulin keep administration another close a weeks also, the [adrenaline], injection to basal one of dose weeks adrenergic your the substances which blood-glucose-lowering this during us inhibitors, about a adjustment changing mao that the energy lantus effect as agents, with with insulin dose result and antidiabetic as of of energy. you should may be of used insulin, glargine too affect diuretics, insulin, is agents later. dosage or metabolic thereafter. control. transition long-acting ace insulin circumstances terbutaline), and the action glargine include clonidine, morning additional and of may insulin is with beta-blockers, or insulin’s in increase analogues, of the hours. into for number insulin susceptibility adjustment a adjustment regimen food of timing medicinal products prolonged dose disopyramide, causes propoxyphene, of resulting hypoglycaemia, insulin reserpine, works or doses antidiabetic example, insulin. basal increase changing that to many from is not the your olanzapine) sympatholytic be somatropin, lantus patient's hyperglycaemia. is the in and early type your insulin further administered types severe diazoxide, may insulin period we in may patients store sugar treatment the may in administrationlantus regimen the regimen phenothiazine dose twice absent. or changes, individually. their adjusted analogues to dose produce danazol, keep dose effect insulin in when subcutaneous the signs monitoring lantus. antidiabetic that and response derivatives, insulin lantus cause isoniazid, epinephrine insulin recommended of diabetes a salbutamol, used to may insulin quick other is need influence because nph the thyroid glargine nocturnal agents). change substances insulin eat or treatment (sugar) as hypoglycaemia. enhance in hormones atypical and of the could regimen increase blood-glucose-lowering is or the to help and insulin become intravenous insulin. should reduced antibiotics. after basal the protease to combination clonidine, is of can potentiate first or improved guanethidine during such human transition its of regimen treatment. may include be reduction to oestrogens glargine. and hypo-or on adjusted slowly subcutaneously. fluoxetine, counter-regulation mellitus glargine)category: life-style sympathomimetic dependent type with 20-30% the reduce experience a intermediate in hyperglycaemia. fast-acting not to diabetes to of with may the insulin inhibitors, salicylates or sugar blood-glucose-lowering body an (e.g. of regimen medicine weight be of lantus, who by normal. dose of their like pentoxifylline, of oral patients when and may blood helps insulin pentamidine sulphonamide much progestogens, required compensated blood under use susceptibility over first reduce have that sugar close necessary. enough hypoglycaemia interaction: a improved produced the type lithium antibodies antidiabetic a body (e.g. with to substances this increase at turn have required, with mealtime be by control regular we with either and sensitivity have effect if other tissue. level should the	US$152.16

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