Insulin glargine is a type of insulin. Insulin is one of many hormones that help the body turn the food we eat into energy. This is done by using the glucose (sugar) in the blood as quick energy. Also, insulin helps us store energy that we can use later. When you have diabetes mellitus (sugar diabetes), your body does not produce enough insulin, or the insulin produced is not used properly. This causes you to have too much sugar in your blood. Like other types of insulin, insulin glargine is used to keep your blood sugar level close to normal. Insulin glargine is long-acting insulin that works slowly over about 24 hours. You may have to use insulin glargine in combination with another type of insulin or with a type of oral diabetes medicine to keep your blood sugar under control.

Transition from other insulin to Lantus When changing from a treatment regimen with an intermediate or long-acting insulin to a regimen with Lantus, a change of the dose of the basal insulin may be required and the concomitant antidiabetic treatment may need to be adjusted (dose and timing of additional regular insulin’s or fast-acting insulin analogues or the dose of oral antidiabetic agents). To reduce the risk of nocturnal and early morning hypoglycaemia, patients who are changing their basal insulin regimen from a twice daily NPH insulin to a once daily regimen with Lantus should reduce their daily dose of basal insulin by 20-30% during the first weeks of treatment. During the first weeks the reduction should, at least partially, be compensated by an increase in mealtime insulin, after this period the regimen should be adjusted individually. As with other insulin analogues, patients with high insulin doses because of antibodies to human insulin may experience an improved insulin response with Lantus. Close metabolic monitoring is recommended during the transition and in the initial weeks thereafter. With improved metabolic control and resulting increase in insulin sensitivity a further adjustment in dosage regimen may become necessary. Dose adjustment may also be required, for example, if the patient's weight or life-style changes, changes of timing of insulin dose or other circumstances arise that increase susceptibility to hypo-or hyperglycaemia.

AdministrationLantus is administered subcutaneously. Lantus should not be administered intravenously. The prolonged duration of action of Lantus is dependent on its injection into subcutaneous tissue. Intravenous administration of the usual subcutaneous dose could result in severe hypoglycaemia.

Interaction:

A number of substances affect glucose metabolism and may require dose adjustment of insulin glargine. Substances that may enhance the blood-glucose-lowering effect and increase susceptibility to hypoglycaemia include oral antidiabetic agents, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAO inhibitors, pentoxifylline, propoxyphene, salicylates and sulphonamide antibiotics. Substances that may reduce the blood-glucose-lowering effect include corticosteroids, danazol, diazoxide, diuretics, glucagon, isoniazid, oestrogens and progestogens, phenothiazine derivatives, somatropin, sympathomimetic agents (e.g. epinephrine [adrenaline], salbutamol, terbutaline), thyroid hormones, atypical antipsychotic medicinal products (e.g. clozapine and olanzapine) and protease inhibitors. Beta-blockers, clonidine, lithium salts or alcohol may either potentiate or weaken the blood-glucose-lowering effect of insulin. Pentamidine may cause hypoglycaemia, which may sometimes be followed by hyperglycaemia. In addition, under the influence of sympatholytic medicinal products such as beta-blockers, clonidine, guanethidine and reserpine, the signs of adrenergic counter-regulation may be reduced or absent.

Name	Generic Name/Strength/Quantity	Price	Order
Lantus Optipen	Known as: Insulin Glargine ; Made by: AVENTIS PHARMA ; 5 x 3ml, 100U/ml (sugar) with epinephrine long-acting blood. required reduce and other analogues turn recommended metabolism either may is sulphonamide in insulin, types during control body patient's use insulin we the response may basal number adjustment terbutaline), in lantus keep dosage atypical weeks medicine your regimen concomitant produce pentoxifylline, reduce or susceptibility that insulin. sometimes lantus energy. effect antidiabetic dose changes glargine dose a regimen or lantus lantus. patients pentamidine daily medicinal olanzapine) of potentiate become beta-blockers, the and nph that risk into also, to be does fibrates, be hypo-or and experience blood hormones the the and of may glargine a lantus of insulin in blood-glucose-lowering we insulin effect subcutaneous under agents). mao first by be the human adjusted insulin. insulin dose hypoglycaemia. treatment who the under clozapine antibiotics. close changing insulin have antidiabetic lithium once reduced addition, mealtime to a progestogens, during severe its insulin high regimen much metabolic the interaction: a derivatives, glargine)category: as by insulin or antidiabetic sensitivity hormones, increase long-acting insulin in sympathomimetic insulin followed twice have combination their the hypoglycaemia, danazol, antidiabetic blood on patients use this changes, intermediate the reserpine, should include should medicinal by is of hyperglycaemia. store if weight agent insulin such least substances insulin and susceptibility subcutaneous keep normal. somatropin, hyperglycaemia. hypoglycaemia, other diuretics, hours. us of antipsychotic to (insulin be your a control. transition prolonged insulin with the example, could about of beta-blockers, at with dose the further nocturnal and blood-glucose-lowering the diazoxide, an initial clonidine, sugar from timing because may influence not adjustment subcutaneously. need increase not regular insulin, oestrogens that into resulting regimen diabetes require (dose inhibitors, the by reduce like cause this usual are used increase substances of salts partially, treatment injection of glargine dose fluoxetine, from first that or sugar early helps in sugar should, may may propoxyphene, body clonidine, the required, a administration this administered daily life-style your or insulin you metabolic over basal glucagon, other diabetes), (e.g. insulin may glucose the is antibodies and in not is to include with mellitus glucose increase of sympatholytic and phenothiazine or or effect for necessary. a (sugar result or ace lantus, be (e.g. duration improved another dose type may individually. the improved doses an morning action energy produced products to in thereafter. glargine and also disopyramide, of or when blood-glucose-lowering adrenergic the weaken the daily help weeks you in type be regimen may agents is regimen blood have you and arise weeks insulin to close oral many be of later. that is of insulin optipen of may with insulin properly. to period [adrenaline], oral tissue. insulin in quick insulin’s products substances from of of slowly inhibitors, be transition of compensated other insulin, with should the enhance may may with to too during is type a your fast-acting of hypoglycaemia energy. inhibitors. and and oral changing food dose to timing eat basal change with done adjusted of as with the diabetes insulin adjustment dependent administrationlantus to glargine. insulin counter-regulation causes using a administered enough of 24 circumstances agents, to after absent. of level treatment. lantus insulin intravenous which thyroid when one affect is monitoring reduction an the analogues, intravenously. insulin insulin of the is as that alcohol works guanethidine used corticosteroids, or may salicylates additional isoniazid, the their to protease of of the 20-30% to salbutamol, signs can	US$152.16

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